The Science of Sweat: Why Running Really Helps Your Brain (and Not Just Your Body)

For decades, exercise has been touted as a cure-all for everything from heart disease to insomnia. But what’s really happening inside your head when you run? Bella Mackie’s Jog On provides a deeply personal answer, but the science is just as compelling.



Running triggers a cascade of neurochemical changes. Endorphins—your body’s natural painkillers—flood the system, creating that famous 'runner’s high.' But there’s more: regular aerobic exercise increases serotonin and dopamine, neurotransmitters that regulate mood and motivation. Mackie’s story echoes these findings; she describes how running quiets her mind, lifts her spirits, and helps her manage the symptoms of anxiety and depression.

Recent research also shows that running boosts neuroplasticity—the brain’s ability to form new connections. This means that movement can literally help rewire negative thought patterns, making it easier to break free from cycles of rumination and self-doubt. Mackie’s incremental progress, from three-minute jogs to longer runs, mirrors the slow, steady changes happening in her brain.



But running isn’t a magic bullet. Mackie is clear that it works best alongside therapy, medication, and support. The science agrees: while exercise can significantly improve mood, it is most effective when combined with other forms of treatment. Routine is key—studies show that even short, regular runs can have lasting benefits.

So how can you harness the power of running for your own mental health? Start small. Focus on consistency, not speed or distance. Celebrate every victory, no matter how minor. And remember: you don’t need to be fast, fit, or fearless to benefit. As Mackie proves, the only requirement is the willingness to try.

Running may not fix everything, but it can help you build a brain—and a life—more resilient to whatever comes next.