
David Perlmutter, MD
A transformative guide revealing uric acid's central role in metabolic and brain health, offering science-backed lifestyle strategies to lower uric acid for disease prevention and vitality.
Humans have 3 to 10 times higher uric acid levels than most other mammals due to evolutionary loss of the uricase enzyme.
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Section 1
8 Sections
Imagine a molecule in your body that quietly orchestrates a symphony of metabolic events, often overlooked because it's been mislabeled as mere waste.
Consider this: about one in five people in the United States carry elevated uric acid levels without showing any symptoms.
Why is this so important? Because uric acid directly affects the function of nitric oxide, a molecule essential for healthy blood vessels and insulin activity. When uric acid rises, it suppresses nitric oxide, causing blood vessels to constrict and insulin to falter.
But uric acid's influence isn't just physical; it reaches into your brain, affecting cognition and memory. Elevated levels correlate with brain shrinkage and faster cognitive decline.
As we embark on this journey, know that understanding uric acid opens a new window into health—a window that has been overlooked for far too long. From here, we will explore how our evolutionary past shaped this molecule's role, how modern diets fuel its rise, and most importantly, how we can reclaim control and lower its impact through lifestyle.
Now that we grasp uric acid’s secret power, let’s dive into the evolutionary tale that explains why humans carry this double-edged sword.
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