
Emeran Mayer
A science-backed guide to the powerful interplay between the gut, brain, and microbiome—and how to harness it for better health.
Over 90% of the body's serotonin is stored in the gut, not the brain.
Section 1
8 Sections
Let’s begin our journey by stepping away from the old, cold view of the body as a mere machine. Imagine, instead, a living, breathing supercomputer—a harmonious ecosystem where each part is deeply linked to the others, and every signal matters. For decades, medicine saw us as cars or clocks: a broken part meant a quick fix, a new piece, or a stronger medicine. But as the years passed, chronic diseases crept into our lives, defying easy explanations or mechanical solutions.
Now, science is unveiling a new picture. Your body is not a collection of isolated parts, but a living network. The gut, for example, is not just a tube for food, but a vast sensory organ, a command center with its own nervous system—the enteric nervous system—packed with as many nerve cells as your spinal cord. It’s also home to more immune cells than your blood or bone marrow, and is the largest storage facility for serotonin, the molecule that shapes mood and well-being.
Think of the gut as your internal supercomputer, gathering, processing, and responding to information every millisecond. Its surface, if spread out, would cover a basketball court, studded with sensors that taste, feel, and analyze every bite you eat.
Yet, our healthcare system, built on the old machine model, spends more than any other country but ranks low in outcomes. We patch up symptoms but often ignore the root causes—the intricate signals between gut, brain, and environment. It’s time to embrace a new paradigm: health as harmony, disease as a disruption in this delicate orchestra.
As we move forward, you’ll see how this ecosystem view opens doors to understanding not just disease, but the fullness of human experience.
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